Place the unbaked pie crust into a 9-inch pie dish and gently press it into place. Trim and crimp edges if desired.
Spread the chopped rhubarb evenly across the bottom of the crust. Make sure it is distributed evenly so each slice contains fruit.
In a large bowl, whisk eggs until smooth. Add sugar, flour, heavy cream, vanilla extract, and salt. Whisk until the mixture is fully combined and creamy with no lumps.
Slowly pour the custard mixture over the rhubarb in the pie crust. Ensure even coverage so the custard fills all spaces between the fruit.
Bake in a preheated oven at 375 degrees Fahrenheit for 45 to 55 minutes. The center should be set with a slight jiggle and the top lightly golden.
Remove from oven and allow the pie to cool fully at room temperature before slicing. This helps the custard set properly.