Preheat the oven to 350 degrees Fahrenheit. Lightly grease a 9x13-inch baking dish with butter or cooking spray and set aside.
Wash the rhubarb stalks well and dry them gently. Trim the ends and chop the rhubarb into small even pieces.
Place the chopped rhubarb into a large bowl. Add granulated sugar, flour, and vanilla extract. Stir until all the rhubarb pieces are coated evenly.
Pour the rhubarb filling into the prepared baking dish. Spread the mixture evenly across the bottom of the dish.
In another bowl, combine flour, oats, brown sugar, cinnamon, and salt. Pour in the melted butter and mix with a fork until crumbly clusters form.
Sprinkle the crumble topping evenly over the rhubarb filling. Keep the topping loose for a crispier texture.
Bake for 40 to 45 minutes or until the topping is golden brown and the filling bubbles around the edges.
Remove from the oven and cool for 10 to 15 minutes before serving. Serve warm with vanilla ice cream or whipped cream if desired.